Article
Human papilloma virus 16 E7 oncogene does not cooperate with RET/PTC 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice.
Oncology research - 1 Jan 2001
Portella G, Borselli C, Santoro M, Gerbasio D, D'Armiento M R, Dumont J E, Ledent C, Rothstein J L, Vecchio G, Fusco A
Abstract excerpt
We have previously reported that the thyroid-targeted expression of the RET/PTC3 oncogene (Tg-RET/PTC3) in transgenic mice induces follicular hyperplasia with papillary architecture, resulting in a modest increase of the thyroid gland volume, followed by the appearance of papillary carcinomas in approximately 1-year-old animals. In order to analyze the genetic alterations that may cooperate with RET/PTC3 in the...
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