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Article

Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.

Molecular biology of the cell - 1 May 2011

Yin Chenlei, Zhang Ru, Xu Yongyu, Chen Qiuyan, Xie Xin

Abstract excerpt

β-arrestins are well known for their roles in desensitization and sequestration of G protein-coupled receptors. Unlike β-arrestin1, β-arrestin2 exhibits a predominant cytoplasmic distribution at steady state. However, the mechanism and functional significance underlying the regulation of β-arrestin2 subcellular localization remains undefined. Here we report that the subcellular localization and function of...

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Identifiers

PMID: 21389118
DOI: 10.1091/mbc.E10-09-0779
PMCID: PMC3084682

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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