X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.

doi:10.1016/s0969-2126(01)00635-9

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Article

X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.

Structure (London, England : 1993) - 1 Aug 2001

Huang D B, Chen Y Q, Ruetsche M, Phelps C B, Ghosh G

Abstract excerpt

BACKGROUND: The proto-oncogene product c-Rel is a Rel/NF-kappaB family transcription factor that plays a critical role in lymphoid cell development and mediates CD28-induced expression of interleukin 2 (IL-2). The CD28 response element (CD28RE) in the IL-2 enhancer is nonameric and similar to the kappaB DNA target sites recognized by p65 homodimers. RESULTS: We have determined and refined the X-ray crystal...

Topics

Amino Acid Sequence
Animals
Anisotropy
Base Sequence
CD28 Antigens
Chickens
Crystallography, X-Ray
DNA
Dimerization
Dose-Response Relationship, Drug
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-2

Models, Molecular

Molecular Sequence Data

Mutation

NF-kappa B

Oncogene Proteins v-rel

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 11587641
DOI: 10.1016/s0969-2126(01)00635-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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