Article
Structural and functional analysis of NF-kappa B. Determinants of DNA binding specificity and protein interaction.
The Journal of biological chemistry - 23 Dec 1994
Schmid R M, Liptay S, Betts J C, Nabel G J
Abstract excerpt
The NF-kappa B transcription factors display a high degree of sequence conservation in a domain initially described in the rel oncogene. Two family members, NF-kappa B1 and NF-kappa B2, have distinct DNA binding properties and functionally distinct effects on different enhancers. NF-kappa B1, for example, binds to the kappa B site from the human immunodeficiency virus (HIV) with approximately 15-fold higher...
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