Article
The N-terminal domain of IkappaB alpha masks the nuclear localization signal(s) of p50 and c-Rel homodimers.
Molecular and cellular biology - 1 May 1998
Latimer M, Ernst M K, Dunn L L, Drutskaya M, Rice N R
Abstract excerpt
Members of the Rel/NF-kappaB family of transcription factors are related to each other over a region of about 300 amino acids called the Rel Homology Domain (RHD), which governs DNA binding, dimerization, and binding to inhibitor. At the C-terminal end of the RHD, each protein has a nuclear local...
Topics
- Binding Sites
- Cell Compartmentation
- Cytoplasm
- DNA-Binding Proteins
- Dimerization
- Humans
- I-kappa B Proteins
- Mutation
- NF-KappaB Inhibitor alpha
- NF-kappa B
- NF-kappa B p50 Subunit
- Nuclear Localization Signals
- Protein Binding
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-rel