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Article

Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation.

Journal of virology - 1 Aug 1998

Nicot C, Tie F, Giam C Z

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) Tax targets I-kappaB alpha and I-kappaB beta for phosphorylation, ubiquitination, and proteasome-mediated degradation, causing the nuclear translocation of NF-kappaB/Rel proteins and transcription induction of many cellular genes. The mechanism by which...

Topics

Binding Sites
Cell Line, Transformed
Chromosome Mapping
Cytoplasm
Gene Expression
Gene Products, tax
HeLa Cells
Human T-lymphotropic virus 1
Humans
Mutagenesis
NF-kappa B
Phenotype
Transcriptional Activation

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Identifiers

PMID: 9658126
DOI: 10.1128/JVI.72.8.6777-6784.1998
PMCID: PMC109886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9658126-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation.PMID 9658126Read ↗

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HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic diseaseSemantic proximity Read ↗

Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.Semantic proximity Read ↗

Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Semantic proximity Read ↗

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