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Article

Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300.

Journal of molecular biology - 28 Sept 2007

Ramírez Julita A, Nyborg Jennifer K

Abstract excerpt

The viral oncoprotein Tax mediates transcriptional activation of human T-cell leukemia virus type 1 (HTLV-1). Both Tax and the cellular transcription factor CREB bind to viral cyclic AMP response elements (vCREs) located in the viral promoter. Tax and serine 133 phosphorylated CREB (pCREB) bound to the HTLV-1 promoter facilitate viral transcription via the recruitment of the large cellular coactivators CBP/p300....

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Share to Cyclic AMP Response Element-Binding Protein
Share to Gene Products, tax

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Human T-lymphotropic virus 1

Share to Myeloid-Lymphoid Leukemia Protein

Share to p300-CBP Transcription Factors

Share to Protein Structure, Secondary

Share to Protein Structure, Tertiary

Source

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Identifiers

PMID: 17707401
DOI: 10.1016/j.jmb.2007.06.062
PMCID: PMC2039700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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