RET-deficient mice: an animal model for Hirschsprung's disease and renal agenesis.

doi:10.1111/j.1365-2796.1995.tb01206.x

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Article

RET-deficient mice: an animal model for Hirschsprung's disease and renal agenesis.

Journal of internal medicine - 1 Oct 1995

Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V

Abstract excerpt

Receptor tyrosine kinases play a critical role in transducing signals involved in cell growth and differentiation. The c-ret proto-oncogene is a member of the receptor tyrosine kinase gene superfamily originally identified by its transforming ability. Somatic mutations of c-ret are responsible fo...

Topics

Animals
Disease Models, Animal
Hirschsprung Disease
Kidney
Kidney Diseases
Mice
Mutagenesis
Mutation
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases

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