Article
Strong association of a novel Tau promoter haplotype in progressive supranuclear palsy.
Neuroscience letters - 5 Oct 2001
de Silva R, Weiler M, Morris H R, Martin E R, Wood N W, Lees A J
Abstract excerpt
The microtubule associated protein, tau, is found in fibrillar lesions that characterise progressive supranuclear palsy (PSP) and related tauopathies. Mutations in the tau gene in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and genetic association of the H1 haplotype of the tau gene with PSP has firmly established a direct role for tau in disease pathogenesis. However, the...
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