Article
Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria.
Parasitology - 1 Sept 2001
Adagu I S, Warhurst D C
Abstract excerpt
In view of the recent discovery (Molecular Cell 6, 861-871) of a (Lys76Thr) codon change in gene pfcrt on chromosome 7 which determines in vitro chloroquine resistance in Plasmodium falciparum, we have re-examined samples taken before treatment in our study in Zaria, Northern Nigeria (Parasitology, 119, 343-348). Drug resistance was present in 5/5 cases where the pfcrt 76Thr codon change was seen (100% positive...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antimalarials
- Child
- Child, Preschool
- Chloroquine
- Drug Resistance
- Humans
- Infant
- Linkage Disequilibrium
- Malaria, Falciparum
- Membrane Proteins
- Membrane Transport Proteins
- Mutation
- Nigeria
- Plasmodium falciparum
- Polymerase Chain Reaction
- Polymorphism, Genetic