Article
The Lys-76-Thr mutation in PfCRT and chloroquine resistance in Plasmodium falciparum isolates from Uganda.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000
Kyosiimire-Lugemwa J, Nalunkuma-Kazibwe A J, Mujuzi G, Mulindwa H, Talisuna A, Egwang T G
Abstract excerpt
Recent molecular studies of chloroquine (CQ) resistance of Plasmodium falciparum have demonstrated an association between a mutation in the PfCRT gene and CQ resistance. We identified wild type and mutant alleles of the PfCRT codon 76 in baseline pre-CQ treatment P. falciparum isolates collected during 1999 and investigated their relationship to CQ efficacy in 3 different sites with different levels of CQ...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.