Article
Field-based evidence for linkage of mutations associated with chloroquine (pfcrt/pfmdr1) and sulfadoxine-pyrimethamine (pfdhfr/pfdhps) resistance and for the fitness cost of multiple mutations in P. falciparum.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2007
Osman Maha E, Mockenhaupt Frank P, Bienzle Ulrich, Elbashir Mustafa I, Giha Hayder A
Abstract excerpt
Mutations in the Plasmodium falciparum pfcrt gene on chromosome 7 and possibly mutations in pfmdr1 on chromosome 5 have a role in conferring resistance against chloroquine (CQ), as do mutations of pfdhfr on chromosome 4 and pfdhps on chromosome 8 in terms of resistance against sulfadoxine/pyrimethamine (SP). The additive role of multiple mutations in the development of resistance to each drug suggests a...
Topics
- Animals
- Antimalarials
- Chloroquine
- Drug Combinations
- Drug Resistance
- Humans
- Mutation
- Plasmodium falciparum
- Pyrimethamine
- Sulfadoxine