Article
Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression.
Diabetes - 1 Oct 2001
Desai U J, Slosberg E D, Boettcher B R, Caplan S L, Fanelli B, Stephan Z, Gunther V J, Kaleko M, Connelly S
Abstract excerpt
Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored the adenoviral vector-mediated overexpression of GK in a diet-induced murine model of type 2...
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