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Article

Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.

EMBO reports - 1 Oct 2001

López-Fraga M, Fernández R, Albar J P, Hahne M

Abstract excerpt

Tumor necrosis factor (TNF) ligand family members are synthesized as transmembrane proteins, and cleavage of the membrane-anchored proteins from the cell surface is frequently observed. The TNF-related ligands APRIL and BLyS and their cognate receptors BCMA/TACI form a two ligand/two receptor system that has been shown to participate in B- and T-cell stimulation. In contrast to BLyS, which is known to be cleaved...

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Identifiers

PMID: 11571266
DOI: 10.1093/embo-reports/kve198
PMCID: PMC1084076

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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