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Article

Tumor necrosis factor-alpha-converting enzyme activities and tumor-associated macrophages in breast cancer.

Immunologic research - 1 Jan 2014

Rego Stephen L, Helms Rachel S, Dréau Didier

Abstract excerpt

The role of the tumor microenvironment especially of tumor-associated macrophages (TAMs) in the progression and metastatic spread of breast cancer is well established. TAMs have primarily a M2 (wound-healing) phenotype with minimal cytotoxic activities. The mechanisms by which tumor cells influence TAMs to display a pro-tumor phenotype are still debated although the key roles of immunomodulatory cytokines...

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Identifiers

PMID: 24072428
DOI: 10.1007/s12026-013-8434-7

Genes

TNF
ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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