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Article

Novel propargylamine-linked nucleosides for high throughput SNP genotyping by MALDI-TOF MS.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2000

Wenzel T, Fröhlich T, Strassburger K, Richter S, Bimmler J, Franke C, Thomas I, Kostrzewa M

Abstract excerpt

The synthesis of positively charged and mass tagged nucleosides containing a quaternary ammonium functionality within the penultimate position of a primer is described. Neutralization of the sugar/thiophosphate backbone by alkylation increases the detection sensitivity in the mass spectrometric analysis by a factor of at least 100. The variable introduction of these novel compounds within the extension primers...

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PMID: 11563137
DOI: 10.1081/NCN-100002451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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