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Article

A novel MALDI-TOF based methodology for genotyping single nucleotide polymorphisms.

Nucleic acids research - 15 Dec 2003

Blondal Thorarinn, Waage Benedikt G, Smarason Sigurdur V, Jonsson Frosti, Fjalldal Sigridur B, Stefansson Kari, Gulcher Jeffery, Smith Albert V

Abstract excerpt

A new MALDI-TOF based detection assay was developed for analysis of single nucleotide polymorphisms (SNPs). It is a significant modification on the classic three-step minisequencing method, which includes a polymerase chain reaction (PCR), removal of excess nucleotides and primers, followed by primer extension in the presence of dideoxynucleotides using modified thermostable DNA polymerase. The key feature of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14654708
DOI: 10.1093/nar/gng156
PMCID: PMC291883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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