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Article

Novel mass tags for single nucleotide polymorphism detection.

Analytical chemistry - 1 Apr 2008

Birikh Klara R, Korshun Vladimir A, Bernad Pablo L, Malakhov Andrei D, Milner Natalie, Khan Safraz, Southern Edwin M, Shchepinov Mikhail S

Abstract excerpt

A new method suitable for single nucleotide polymorphism detection and other applications based on oligonucleotide probe extension has been developed. The method is based on mass spectrometry and utilizes a single surface for affinity purification of extended probes and matrix-independent desorption/ionization of the cleavable labels. A new family of sulfur-linked laser-cleavable trityl labels with vastly...

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PMID: 17973350
DOI: 10.1021/ac071291y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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