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Genosnip: SNP genotyping by MALDI-TOF MS using photocleavable oligonucleotides.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2000

Wenzel T, Elssner T, Fahr K, Bimmler J, Richter S, Thomas I, Kostrzewa M

Abstract excerpt

A photocleavable o-nitrobenzyl CE phosphoramidite building-block was synthesised and incorporated within oligonucleotides. After allele-specific primer extension, desalting was performed using genostrep purification plates. Release of the SNP information containing part through photocleavage created shortened molecules that are easily accessible for MALDI-TOF analysis. Additionally, incorporation of mass modified...

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PMID: 14565470
DOI: 10.1081/NCN-120023038

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