Article
Discovery and identification of sequence polymorphisms and mutations with MALDI-TOF MS.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
van den Boom Dirk, Ehrich Mathias
Abstract excerpt
Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has become a widely used technology for the detection of nucleic acids. In this chapter we introduce its use for the discovery of novel sequence polymorphisms and the identification of known DNA changes. We first provide a brief overview about MALDI-TOF MS analysis of nucleic acids. We then elucidate the concept of...
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