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Article

High level multiplex genotyping by MALDI-TOF mass spectrometry.

Nature biotechnology - 1 Dec 1998

Ross P, Hall L, Smirnov I, Haff L

Abstract excerpt

A primer extension assay is used to perform highly multiplexed genotyping of single nucleotide polymorphisms (SNPs) present in genomic DNA amplified by a multiplex PCR. The assay uses matrix-assisted laser desorption ionization time-of-flight mass spectrometry to accurately measure the masses of short oligonucleotide primers extended by a single dideoxynucleotide. The multiplexed genotyping assays rely on the...

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PMID: 9853617
DOI: 10.1038/4328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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