Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with Camptothecin

1 May 2002

Abstract excerpt

Treatment of cells with the anti-cancer drug camptothecin (CPT) induces topoisomerase I (Top1)-mediated DNA damage, which in turn affects cell proliferation and survival. In this report, we demonstrate that treatment of the wild-type HCT116 (wt HCT116) human colon cancer cell line and the isogenic p53(-/-) HCT116 and p21(-/-) HCT116 cell lines with a high concentration (250 nm) of CPT resulted in apoptosis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11877436
DOI: 10.1074/jbc.m112401200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with CamptothecinPMID 11877436Read ↗

Role of the p53/p21 system in the response of human colon carcinoma cells to DoxorubicinSemantic proximity Read ↗

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.Semantic proximity Read ↗

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.Semantic proximity Read ↗

Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent MechanismSemantic proximity Read ↗

Inactivation of p21Sensitizes Cells to Apoptosis via an Increase of Both p14ARF and p53 Levels and an Alteration of the Bax/Bcl-2 RatioSemantic proximity Read ↗

Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells.Semantic proximity Read ↗

Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapseSemantic proximity Read ↗

p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.Semantic proximity Read ↗

Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.Semantic proximity Read ↗

Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines.Semantic proximity Read ↗

Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells.Semantic proximity Read ↗

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.