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Article

Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line.

Oncogene - 4 Mar 2004

Abal Miguel, Bras-Goncalves Rui, Judde Jean-Gabriel, Fsihi Hafida, De Cremoux Patricia, Louvard Daniel, Magdelenat Henri, Robine Sylvie, Poupon Marie-France

Abstract excerpt

Mutations in the tumor-suppressor gene p53 have been associated with advanced colorectal cancer (CRC). Irinotecan (CPT-11), a DNA topoisomerase 1 inhibitor, has been recently incorporated to the adjuvant therapy. Since the DNA-damage checkpoint depends on p53 activation, the status of p53 might critically influence the response to CPT-11. We analysed the sensitivity to CPT-11 in the human colon cancer cell line...

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PMID: 15001986
DOI: 10.1038/sj.onc.1207299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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