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p53-Dependent Induction of p21Cip1/WAF1/Sdi1 Protects against Oxygen-Induced Toxicity

1 Oct 2001

Abstract excerpt

The beneficial effects of supplemental oxygen delivered to patients suffering from acute respiratory distress is offset by its reduction to genotoxic reactive oxygen species (ROS) that inhibit proliferation and kill pulmonary cells. Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by...

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PMID: 11568365
DOI: 10.1093/toxsci/63.2.214

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