Article
p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage.
Oncogene - 2 Jul 1998
Bissonnette N, Hunting D J
Abstract excerpt
Cells expressing the R273H mutant of p53, which lacks sequence specific DNA binding capacity, do not undergo cell cycle arrest in G1 following exposure to ionizing or UV radiation because of their inability to induce p21Waf1/Cip1, a cyclin-dependent kinase inhibitor and downstream mediator of p53...
Topics
- Apoptosis
- Carcinoma
- Caspase 3
- Caspases
- Culture Media, Serum-Free
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- Cysteine Endopeptidases
- DNA Damage
- G1 Phase
- Mimosine
- Mutation
- Periodicity
- Poly(ADP-ribose) Polymerases
- RNA Polymerase II
- Skin Neoplasms
- Tumor Cells, Cultured