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Article

Lethal mutagenesis of bacteria.

Genetics - 1 Oct 2008

Bull James J, Wilke Claus O

Abstract excerpt

Lethal mutagenesis, the killing of a microbial pathogen with a chemical mutagen, is a potential broad-spectrum antiviral treatment. It operates by raising the genomic mutation rate to the point that the deleterious load causes the population to decline. Its use has been limited to RNA viruses because of their high intrinsic mutation rates. Microbes with DNA genomes, which include many viruses and bacteria, have...

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Identifiers

PMID: 18780744
DOI: 10.1534/genetics.108.091413
PMCID: PMC2567356

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