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Article

Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5.

Molecular and cellular biology - 1 Oct 2004

Wen Huajie, Watry Debbie D, Marcondes M Cecilia G, Fox Howard S

Abstract excerpt

Claudin-5 is a protein component of many endothelial tight junctions, including those at the blood-brain barrier, a barrier that limits molecular exchanges between the central nervous system and the circulatory system. To test the contribution of claudin-5 to this barrier function of tight junctions, we expressed murine claudin-5 in Madin-Darby canine kidney II cells. The result was a fivefold increase in...

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Identifiers

PMID: 15367662
DOI: 10.1128/MCB.24.19.8408-8417.2004
PMCID: PMC516730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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