Article
Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.
Molecular biology of the cell - 1 Dec 2011
Chai Zhifang, Goodenough Daniel A, Paul David L
Abstract excerpt
The three connexins expressed in the ocular lens each contain PDZ domain-binding motifs directing a physical association with the scaffolding protein ZO-1, but the significance of the interaction is unknown. We found that Cx50 with PDZ-binding motif mutations did not form gap junction plaques or induce cell-cell communication in HeLa cells, whereas the addition of a seven-amino acid PDZ-binding motif restored...
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