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Article

Inhibiting cadherin function by dominant mutant E-cadherin expression increases the extent of tight junction assembly.

Journal of cell science - 1 Mar 2000

Troxell M L, Gopalakrishnan S, McCormack J, Poteat B A, Pennington J, Garringer S M, Schneeberger E E, Nelson W J, Marrs J A

Abstract excerpt

Previous studies have shown that induction of cadherin-mediated cell-cell adhesion leads to tight junction formation, and that blocking cadherin-mediated cell-cell adhesion inhibits tight junction assembly. Here we report analysis of tight junction assembly in MDCK cells overexpressing a mutant E-cadherin protein that lacks an adhesive extracellular domain (T151 cells). Mutant E-cadherin overexpression caused a...

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Source

Identifiers

PMID: 10683147
DOI: 10.1242/jcs.113.6.985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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