Article
A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.
The Journal of biological chemistry - 9 Nov 2001
Casula S, Shmukler B E, Wilhelm S, Stuart-Tilley A K, Su W, Chernova M N, Brugnara C, Alper S L
Abstract excerpt
K-Cl cotransport regulates cell volume and chloride equilibrium potential. Inhibition of erythroid K-Cl cotransport has emerged as an important adjunct strategy for the treatment of sickle cell anemia. However, structure-function relationships among the polypeptide products of the four K-Cl cotransporter (KCC) genes are little understood. We have investigated the importance of the N- and C-terminal cytoplasmic...
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