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Article

Barttin modulates trafficking and function of ClC-K channels.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jul 2006

Scholl Ute, Hebeisen Simon, Janssen Audrey G H, Müller-Newen Gerhard, Alekov Alexi, Fahlke Christoph

Abstract excerpt

Barttin is an accessory subunit of a subgroup of ClC-type chloride channels expressed in renal and inner ear epithelia. In this study, we examined the effects of barttin on two ClC-K channel isoforms, rat ClC-K1 and human ClC-Kb, using heterologous expression, patch clamping, confocal imaging, and flow cytometry. In the absence of barttin, only a small percentage of rClC-K1 and hClC-Kb channels are inserted into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16849430
DOI: 10.1073/pnas.0601631103
PMCID: PMC1544099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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