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Article

Rare mutations in the human Na-K-Cl cotransporter (NKCC2) associated with lower blood pressure exhibit impaired processing and transport function.

American journal of physiology. Renal physiology - 1 Apr 2011

Monette Michelle Y, Rinehart Jesse, Lifton Richard P, Forbush Biff

Abstract excerpt

The Na-K-Cl cotransporter (NKCC2) is the major salt transport pathway in the thick ascending limb of Henle's loop and is part of the molecular mechanism for blood pressure regulation. Recent screening of ∼3,000 members of the Framingham Heart Study identified nine rare independent mutations in the gene encoding NKCC2 (SLC12A1) associated with clinically reduced blood pressure and protection from hypertension (Ji...

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Identifiers

PMID: 21209010
DOI: 10.1152/ajprenal.00552.2010
PMCID: PMC3074999

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