Article
Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates.
Cell death and differentiation - 1 Apr 2001
U M, Miyashita T, Ohtsuka Y, Okamura-Oho Y, Shikama Y, Yamada M
Abstract excerpt
A growing number of inherited neurodegenerative disorders, including Huntington's disease, have been shown to be caused by the expansion of CAG/polyglutamine repeats. The molecular mechanism underlying these disorders, however, has yet to be clarified. We and others previously demonstrated that caspase-8 was activated by proteolysis in association with the expression of extended polyglutamine. Here, we further...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.