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Article

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

Neuron - 1 Mar 1999

Sánchez I, Xu C J, Juo P, Kakizaka A, Blenis J, Yuan J

Abstract excerpt

We show here that caspase-8 is required for the death of primary rat neurons induced by an expanded polyglutamine repeat (Q79). Expression of Q79 recruited and activated caspase-8. Inhibition of caspase-8 blocked polyglutamine-induced cell death. Coexpression of Q79 with the caspase inhibitor Crm...

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PMID: 10197541
DOI: 10.1016/s0896-6273(00)80716-3

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FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10197541-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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