Article
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
The Journal of biological chemistry - 26 Mar 1999
Ellerby L M, Andrusiak R L, Wellington C L, Hackam A S, Propp S S, Wood J D, Sharp A H, Margolis R L, Ross C A, Salvesen G S, Hayden M R, Bredesen D E
Abstract excerpt
Dentatorubropallidoluysian atrophy (DRPLA) is one of eight autosomal dominant neurodegenerative disorders characterized by an abnormal CAG repeat expansion which results in the expression of a protein with a polyglutamine stretch of excessive length. We have reported recently that four of the gene products (huntingtin, atrophin-1 (DRPLA), ataxin-3, and androgen receptor) associated with these open reading frame...
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