Article
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Cell death and differentiation - 1 Apr 2004
Hermel E, Gafni J, Propp S S, Leavitt B R, Wellington C L, Young J E, Hackam A S, Logvinova A V, Peel A L, Chen S F, Hook V, Singaraja R, Krajewski S, Goldsmith P C, Ellerby H M, Hayden M R, Bredesen D E, Ellerby L M
Abstract excerpt
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder resulting in selective neuronal loss and dysfunction in the striatum and cortex. The molecular pathways leading to the selectivity of neuronal cell death in HD are poorly understood. Proteolytic processing of full-length mutant huntingtin (Htt) and subsequent events may play an important role in the selective neuronal cell...
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