Article
Recombinational repair of chromosomal DNA double-strand breaks generated by a restriction endonuclease.
Molecular microbiology - 1 Aug 2001
Cromie G A, Leach D R
Abstract excerpt
DNA double-strand break repair can be accomplished by homologous recombination when a sister chromatid or a homologous chromosome is available. However, the study of sister chromatid double-strand break repair in prokaryotes is complicated by the difficulty in targeting a break to only one copy of two essentially identical DNA sequences. We have developed a system using the Escherichia coli chromosome and the...
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