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Article

The recombination hot spot chi activates RecBCD recombination by converting Escherichia coli to a recD mutant phenocopy.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 1995

Myers R S, Kuzminov A, Stahl F W

Abstract excerpt

The products of the recB and recC genes are necessary for conjugal recombination and for repair of chromosomal double-chain breaks in Escherichia coli. The recD gene product combines with the RecB and RecC proteins to comprise RecBCD enzyme but is required for neither recombination nor repair. On the contrary, RecBCD enzyme is an exonuclease that inhibits recombination by destroying linear DNA. The RecD ejection...

Topics

Bacteriophage lambda
Base Sequence
Chromosomes, Bacterial
Cosmids
DNA Replication
DNA, Bacterial
DNA, Viral
Escherichia coli
Escherichia coli Proteins
Exodeoxyribonuclease V

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exodeoxyribonucleases

Genes, Bacterial

Genotype

Molecular Sequence Data

Mutagenesis

Plasmids

Recombination, Genetic

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 7603978
DOI: 10.1073/pnas.92.14.6244
PMCID: PMC41494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7603978-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The recombination hot spot chi activates RecBCD recombination by converting Escherichia coli to a recD mutant phenocopy.PMID 7603978Read ↗

Chi and the RecBC D enzyme of Escherichia coli.Semantic proximity Read ↗

Reversible inactivation of the Escherichia coli RecBCD enzyme by the recombination hotspot chi in vitro: evidence for functional inactivation or loss of the RecD subunit.Semantic proximity Read ↗

Nuclease activity is essential for RecBCD recombination in Escherichia coli.Semantic proximity Read ↗

Old and new concepts for the role of chi in bacterial recombination.Semantic proximity Read ↗

Inhibition of the recBCD-dependent activation of Chi recombinational hot spots in SOS-induced cells of Escherichia coli.Semantic proximity Read ↗

Role of the Escherichia coli recombination hotspot, chi, in RecABCD-dependent homologous pairing.Semantic proximity Read ↗

A RecA mutant, RecA(730), suppresses the recombination deficiency of the RecBC(1004)D-chi* interaction in vitro and in vivo.Semantic proximity Read ↗

A domain of RecC required for assembly of the regulatory RecD subunit into the Escherichia coli RecBCD holoenzyme.Semantic proximity Read ↗

Chi hotspot activity in Escherichia coli without RecBCD exonuclease activity: implications for the mechanism of recombination.Semantic proximity Read ↗

Intersubunit signaling in RecBCD enzyme, a complex protein machine regulated by Chi hot spots.Semantic proximity Read ↗

A single mutation, RecB(D1080A,) eliminates RecA protein loading but not Chi recognition by RecBCD enzyme.Semantic proximity Read ↗

Chi-dependent intramolecular recombination in Escherichia coli.Semantic proximity Read ↗

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