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Article

Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury.

Developmental biology - 15 Nov 2000

Harrison S M, Houzelstein D, Dunwoodie S L, Beddington R S

Abstract excerpt

We describe the identification, biochemical characterisation, and mutation of a novel mouse gene: Sp5. Sp5 encodes a protein having a C-terminal C(2)H(2) zinc finger domain closely related to that of the transcription factor Sp1. In vitro, DNA binding studies show that it binds to the GC box, a DNA motif present in the promoter of a very large number of genes, including Brachyury, and recognised by members of the...

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Identifiers

PMID: 11071760
DOI: 10.1006/dbio.2000.9878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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