Article

Molecular evolution of the Angiotensin II receptors AT1 and AT2: Specificity of the sodium binding site in amniota

2021-06-04

Abstract excerpt

<h4>ABSTRACT</h4> In vertebrates, the octopeptide angiotensin II (AngII) is an important in vivo regulator of the cardiovascular system. It acts mainly through two G protein-coupled receptors, AT1 and AT2. To better understand the interplay between these receptors throughout the evolution of the renin-angiotensin system (RAS), we combined a phylogenetic study to electrostatics computations and molecular dynamics...

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Literature Corpus work: 2567f1d6-dac3-57e8-b12a-350f999d7909
DOI: 10.1101/2021.06.04.446765

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