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Article

DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

The Journal of biological chemistry - 15 Apr 2005

Fernandes Norvin, Sun Yingli, Chen Shujuan, Paul Proma, Shaw Reuben J, Cantley Lewis C, Price Brendan D

Abstract excerpt

The ATM protein kinase regulates the response of the cell to DNA damage by associating with and then phosphorylating proteins involved in cell cycle checkpoints and DNA repair. Here, we report on deletion studies designed to identify protein domains required for ATM to phosphorylate target proteins and to control cell survival following exposure to ionizing radiation. Deletion studies demonstrated that amino...

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Source

Identifiers

PMID: 15713674
DOI: 10.1074/jbc.M412065200

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.PMID 15713674Read ↗

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