Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.

Cell cycle (Georgetown, Tex.) - 1 May 2008

White Jason S, Choi Serah, Bakkenist Christopher J

Abstract excerpt

Mutations in the ATM kinase cause the neurodegenerative disorder ataxia telangiectasia (A-T) and affected individuals are exquisitely radiation-sensitive and cancer-prone. Cells derived from A-T individuals contain chromosome aberrations and exhibit profound cellular radiosensitivity. ATM is an apical kinase critical for the activation of cell cycle checkpoints and the induction of apoptosis in irradiated cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to Chromosome Breakage

Share to G2 Phase

Share to Gamma Rays

Share to Radiation Tolerance

Share to S Phase

Source

Identifiers

PMID: 18418045
DOI: 10.4161/cc.7.9.5961

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.PMID 18418045Read ↗

Inhibition of ATM kinase activity does not phenocopy ATM protein disruptionSemantic proximity Read ↗

Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid ExchangeSemantic proximity Read ↗

The role of ATM in DNA damage responses and cancer.Semantic proximity Read ↗

Molecular perspectives on cancer, the cell cycle and the inherited disorder ataxia-telangiectasia.Semantic proximity Read ↗

Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.Semantic proximity Read ↗

Ataxia-telangiectasia and cellular responses to DNA damage.Semantic proximity Read ↗

ATM&A Key Determinant of Multiple Cellular Responses to IrradiationSemantic proximity Read ↗

ATM and related protein kinases: safeguarding genome integrity.Semantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

Multiple roles of ATM in monitoring and maintaining DNA integritySemantic proximity Read ↗

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.Semantic proximity Read ↗

Pathogenesis of ataxia-telangiectasia: the next generation of ATM functionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.