Article
Obsessive-compulsive disorder and a novel polymorphism adjacent to the oestrogen response element (ERE 6) upstream from the COMT gene.
Psychiatric genetics - 1 Jun 2001
Kinnear C, Niehaus D J, Seedat S, Moolman-Smook J C, Corfield V A, Malherbe G, Potgieter A, Lombard C, Stein D J
Abstract excerpt
Family and twin studies have consistently provided evidence for involvement of genetic mechanisms in obsessive-compulsive disorder (OCD). This has given rise to association studies involving several candidate genes in an endeavour to identify susceptibility factors. One of the more promising candidate genes appears to be the catecol-O-methyltransferase (COMT) gene. Recent association studies in North American and...
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