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Article

Association between the COMT locus and obsessive-compulsive disorder in females but not males.

American journal of medical genetics - 8 Jan 2002

Alsobrook John P, Zohar Ada H, Leboyer Marion, Chabane Nadia, Ebstein Richard P, Pauls David L

Abstract excerpt

A polymorphism in the coding region of catechol-O-methyltransferase gene (COMT) was previously reported to be associated with obsessive-compulsive disorder (OCD), particularly in male probands. We attempted to replicate the previous finding using a family-based genetic design in haplotype relative risk (HRR) and transmission disequilibrium (TDT) analyses. Fifty-six OCD probands and their parents were genotyped...

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Source

Identifiers

PMID: 11840516
DOI: 10.1002/ajmg.10040

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association between the COMT locus and obsessive-compulsive disorder in females but not males.PMID 11840516Read ↗

Association between homozygosity at the COMT gene locus and obsessive compulsive disorder.Semantic proximity Read ↗

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.Semantic proximity Read ↗

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.Semantic proximity Read ↗

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.Semantic proximity Read ↗

Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males.Semantic proximity Read ↗

Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.Semantic proximity Read ↗

COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study.Semantic proximity Read ↗

Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder.Semantic proximity Read ↗

Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism.Semantic proximity Read ↗

No association between anxiety disorders and catechol-O-methyltransferase polymorphism.Semantic proximity Read ↗

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