Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase and Gilles de la Tourette syndrome.

Molecular psychiatry - 1 Sept 1999

Barr C L, Wigg K G, Sandor P

Abstract excerpt

Gilles de la Tourette syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. Individuals with TS often have symptoms of obsessive compulsive disorder (OCD) and these symptoms are thought to be an alternative expression of the TS gene(s) in TS families. In this paper we test for linkage of the functional polymorphism in the catechol-O-methyltransferase (COMT) gene to TS and OCD in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Family Health
Share to COMT gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Obsessive-Compulsive Disorder

Share to Phenotype

Share to Polymorphism, Genetic

Share to Tourette Syndrome

Source

Identifiers

PMID: 10523824
DOI: 10.1038/sj.mp.4000549

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase and Gilles de la Tourette syndrome.PMID 10523824Read ↗

Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorder.Semantic proximity Read ↗

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.Semantic proximity Read ↗

Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.Semantic proximity Read ↗

Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.Semantic proximity Read ↗

An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette's syndrome.Semantic proximity Read ↗

Association between the COMT locus and obsessive-compulsive disorder in females but not males.Semantic proximity Read ↗

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.Semantic proximity Read ↗

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families.Semantic proximity Read ↗

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.Semantic proximity Read ↗

Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele.Semantic proximity Read ↗

A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.