Article
Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder.
Depression and anxiety - 1 Jan 2003
Erdal M Emin, Tot Senel, Yazici Kemal, Yazici Aylin, Herken Hasan, Erdem Pervin, Derici Ebru, Camdeviren Handan
Abstract excerpt
The COMT gene has been implicated to be involved in the pathogenesis of obsessive-compulsive disorder (OCD) and various other psychiatric disorders. COMT enzyme activity is governed by a common genetic polymorphism at codon 158 that results in substantial 3- to 4-fold variation in enzymatic activity [a high-activity COMT variant (H) and a low activity variant (L)]. This study evaluates the association between OCD...
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