Article
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997
Karayiorgou M, Altemus M, Galke B L, Goldman D, Murphy D L, Ott J, Gogos J A
Abstract excerpt
In the present study, we address the role of the gene for catechol-O-methyltransferase (COMT), a key modulator of dopaminergic and noradrenergic neurotransmission, in the genetic predisposition to obsessive-compulsive disorder (OCD). We show that a common functional allele of this gene, which results in a 3- to 4-fold reduction in enzyme activity, is significantly associated in a recessive manner with...
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