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Article

Association of catechol-O-methyl transferase (COMT) gene -287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2011

Liu Shiguo, Liu Yanhui, Wang Haiping, Zhou Ruiling, Zong Jinbao, Li Changgui, Zhang Xinhua, Ma Xu

Abstract excerpt

Several studies suggested a genetic component in the etiology of obsessive-compulsive disorder (OCD). COMT involves in the degradation of dopamine and norepinephrin. As another functional SNP locus, COMT -287A/G polymorphism showed an effect on enzyme activity, suggesting that it may influence brain dopamine levels. To identify association of COMT -287A/G polymorphism with susceptibility to OCD in Chinese Han...

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Identifiers

PMID: 21344643
DOI: 10.1002/ajmg.b.31173

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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