Article
Genetic analysis of the mu-opioid receptor in alcohol-dependent individuals.
Alcohol (Fayetteville, N.Y.) - 1 Jun 2001
Rommelspacher H, Smolka M, Schmidt L G, Samochowiec J, Hoehe M R
Abstract excerpt
On the basis of various study results, it is suggested that the ethanol-induced activation of the endogenous opioid system may play an important role in mediating the reinforcing effects of ethanol. The mesolimbic dopamine reward system is activated by both ethanol and opioids, and genetic differences in the sensitivity of the endogenous opioid system to alcohol may be an important factor determining the risk for...
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