Article
Allelic and somatic variations in the endogenous opioid system of humans.
Pharmacology & therapeutics - 1 Sept 2001
Mayer P, Höllt V
Abstract excerpt
People with a genetic predisposition for substance abuse have defects in genes for the opioid peptides and receptors. A high number of polymorphisms have been detected in the mu-opioid receptor, some of which result in pharmacological alterations. The opioid peptide proopiomelanocortin proved extraordinarily rich in mutations that often lead to severe phenotypical consequences. Prodynorphin displays a polymorphic...
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